Clinical Significance of Serum IL-15 and IL-17 in Relation to Rheumatoid Arthritis' Severity and Activity

ABSTRACT: In this study, we measured serum IL-15 and IL-17 levels in a cohort of patients with rheumatoid arthritis (RA) in order to assess their relevance with the disease’s activity and severity, as well as delineating any potential correlation with various clinical and laboratory parameters routinely used to evaluate RA disease activity and severity. Peripheral blood samples were collected from all recruits and used for the estimation of serum IL-15, IL-17, anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor (RF) and C-reactive protein (CRP) as well as erythrocyte sedimentation rate (ESR). RA activity and severity were also determined using disease activity score 28 (DAS28) as well as tender joint count (TJC) and swollen joint count (SJC) respectively. RA patients showed significantly higher mean serum IL-15 and IL-17 levels than controls (P< 0.01). In addition, IL-15 and IL-17 serum levels were found to be significantly higher in RA patient with active disease in comparison to those in remission. Patient with high disease activity showed significantly higher mean serum IL-17 levels than moderate and low disease activity groups while no significant difference was observed in the mean serum IL-15 levels among the three groups. No significant correlation was noted between IL-15 serum level and RF, CRP, ESR and anti-CCP but it was significantly correlated with DAS28, TJC and SJC. Significant positive correlations of serum IL-17 level were found with ESR, CRP, anti-CCP, DAS28, TJC, and SJC, as well as a direct significant correlation between IL-15 and IL-17 serum levels.

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST823 | biostudies-other |

REPOSITORIES: biostudies-other