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Study FP013NO: Evaluation of the Acute Toxicity, Gene Expression, Protein Expression, Metabolite Production, Clinical Chemistry and Pathology Profile Following an Oral Administration of Compound IMM125 to Rats

ABSTRACT: Repeated dose 14-day toxicity study in adult male rats (Rattus norvegicus), Wistar strain, using chemical compound FP013NO, administered daily orally, sponsored by Novartis, funded by European Union Framework Program 6 - Innovative Medicines Initiatives - Integrated Project Predictive Toxicology (EU FP6 InnoMed PredTox: LSHB-CT-2005-518170), The study will examine the gene, protein and metabolite profiles, along with traditional toxicological endpoint information in the liver, kidney, blood and urine of rats 1-14 days after exposure. By design, low doses lie between No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL). An increase in kidney proximal tubule damage is observed in animals exposed to high dose and longest duration.

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PROVIDER: S-DIXA-023 | biostudies-other |

REPOSITORIES: biostudies-other

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