Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

ABSTRACT: Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines. The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. To identify novel oncogenes, activated by gene amplification, we performed high-resolution CGH (Comparative Genome Hybridization) analysis on cDNA microarrays and compared DNA copy number and mRNA expression levels in lung cancer cell lines. We have performed both microarrays (expression and CGH) in a set of 8 human lung cancer cell lines: Calu3, H23, H441, A427, H522, A549, H1299, H2126.

ORGANISM(S): Homo sapiens

SUBMITTER: Medina PP

PROVIDER: S-ECPF-GEOD-14079 | biostudies-other | 2009 Apr

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

Project description:Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines.

2009-03-03 | GSE14079 | GEO

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

Project description:Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines. The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. To identify novel oncogenes, activated by gene amplification, we performed high-resolution CGH (Comparative Genome Hybridization) analysis on cDNA microarrays and compared DNA copy number and mRNA expression levels in lung cancer cell lines. We have performed both microarrays (expression and CGH) in a set of 8 human lung cancer cell lines: Calu3, H23, H441, A427, H522, A549, H1299, H2126.

2010-05-22 | E-GEOD-14079 | biostudies-arrayexpress

Comparative genomic hybridization of human small cell lung cancer cell lines

Project description:CGH analysis of SCLC (small cell lung cancer) cell lines

2007-04-15 | E-MEXP-1008 | biostudies-arrayexpress

Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays.

Project description:To investigate the genomic aberrations that are involved in lung tumorigenesis and therefore may be developed as biomarkers for lung cancer diagnosis, we characterized the genomic copy number changes associated with individual genes in 14 tumors from patients with primary non small cell lung cancer (NSCLC). Six squamous cell carcinomas (SQCAs) and eight adenocarcinomas (ADCAs) were examined by high-resolution comparative genomic hybridization (CGH) analysis of cDNA microarray. The SQCAs and ADCAs shared common frequency distributions of recurrent genomic gains of 63 genes and losses of 72 genes. Cluster analysis using 57 genes defined the genomic differences between these two major histologic types of NSCLC. Genomic aberrations from a set of 18 genes showed distinct difference of primary ADCAs from their paired normal lung tissues. The genomic copy number of four genes was validated by fluorescence in situ hybridization of 32 primary NSCLC tumors, including those used for cDNA microarray CGH analysis; a strong correlation with cDNA microarray CGH data emerged. The identified genomic aberrations may be involved in the initiation and progression of lung tumorigenesis and, most importantly, may be developed as new biomarkers for the early detection and classification of lung cancer.

| S-EPMC1531667 | biostudies-literature

Transcription profiling, comparative genomic hybridization, genotyping and methylation profiling by array of human breast cancer cell lines

Project description:Integrative analysis of breast cancer cell lines, using expression, comparative genomics, SNP and methylation profiling

| S-ECPF-TABM-928 | biostudies-other

Genomic profiling of pancreatic cancer cell lines by array-based comparative genomic hybridization

Project description:In this study, we determined the genomic profiles of pancreatic cancer cell lines.

2016-01-22 | GSE65175 | GEO

Comparative genomic hybridization of hiPSC stem cell lines.

Project description:The Purpose of this series of experiments is to identify copy number variations, duplications, and deletions in human induced pluripotent stem (hiPSC) cell lines.

2012-01-07 | GSE33484 | GEO

Gene Expression data from 56 lung cancer cell lines

Project description:Highlighting the gene expression characteristics of a large panel of lung cancer cell lines. Microarrays were used to explore and detail the global gene expression profile of 56 lung cancer cell lines Gene expression was measured and recorded on HG-U133A chips in a large panel of lung cancer cell lines under ATCC recommended growth conditions

| S-ECPF-GEOD-47206 | biostudies-other

Genomic profiling of 49 gastric cancer cell lines by array-based comparative genomic hybridization

Project description:In this study, we investigated amplifications and deletions of 49 gastric cancer cell lines by 244k oligonucleotide-based array comparative genomic hybridization.

2016-12-01 | GSE74839 | GEO

Array comparative genomic hybridization analysis of metastatic lung tumors

Project description:Comparative genomic hybridization analysis for detection of recurring gene copy number variation (CNV) among a set of lung cancer mestastatic brain tumors DNA was isolated and analyzed in a two-color experiment using Cancer CGH+SNP 180Kx4 arrays from Agilent and Agilent SureScan system: Cy5-labeled specimen DNA and Cy3-labeled Agilent characterized normal human reference DNA

2020-12-04 | GSE157515 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data