Transcription profiling by array of human glioblastoma samples after treatment with LY2109761

ABSTRACT: TGF-beta has an oncogenic response in glioblastoma and it is considered to be a therapeutic target. We evaluated the effect of TGF-beta inhibition in glioblastoma. Differential gene expression analysis of patient-derived primary cultured glioblastoma cells treated with the TGF-beta receptor inhibitor, LY2109761 11 patient-derived cell cultures from 11 patients were treated with 2microM of the TGF-beta receptor inhibitor, LY2109761, for 3 hours or left untreated and RNA was isolated and microarray analysis was performed

ORGANISM(S): Homo sapiens

SUBMITTER: Anido J 

PROVIDER: S-ECPF-GEOD-23935 | biostudies-other | 2010 Dec

REPOSITORIES: biostudies-other