Browse
Submit Data
Databases
API
Help

Dataset Information

43 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide analysis of microRNA expression in surgical specimens of primary glioblastoma multiform

ABSTRACT: MicroRNA has a great potential in predicting survival of cancer patient. We used a genome-wide microRNA expression profiling to identify a miRNA signature for the prediction of clinical outcome of primary GBM patients. Total RNA obtained from 82 surgical specimens of primary glioblastoma multiform and 5 normal brain tissues from areas surrounding arteriovenous malformations (AVM) as control.

ORGANISM(S): Homo sapiens

SUBMITTER: Zhang W

PROVIDER: S-ECPF-GEOD-25631 | biostudies-other | 2012 Jun

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Genome-wide analysis of gene expression in surgical specimens of primary glioblastoma multiform

Project description:We used a genome-wide coding gene expression profiling to identify a gene signature for the molecular classification or prognostic prediction of primary GBMs. Total RNA obtained from 21 surgical specimens of primary glioblastoma multiform.

| S-ECPF-GEOD-25630 | biostudies-other

Genome-wide analysis of microRNA expression in surgical specimens of primary glioblastoma multiform

2012-07-13 | GSE25631 | GEO

Genome-wide analysis of microRNA expression in surgical specimens of primary glioblastoma multiform

Project description:MicroRNA has a great potential in predicting survival of cancer patient. We used a genome-wide microRNA expression profiling to identify a miRNA signature for the prediction of clinical outcome of primary GBM patients. Total RNA obtained from 82 surgical specimens of primary glioblastoma multiform and 5 normal brain tissues from areas surrounding arteriovenous malformations (AVM) as control.

2012-07-12 | E-GEOD-25631 | biostudies-arrayexpress

Genome-wide analysis of gene expression in surgical specimens of primary glioblastoma multiform

Project description:We used a genome-wide coding gene expression profiling to identify a gene signature for the molecular classification or prognostic prediction of primary GBMs.

2012-07-13 | GSE25630 | GEO

Genome-wide analysis of gene expression in surgical specimens of primary glioblastoma multiform

2012-07-12 | E-GEOD-25630 | biostudies-arrayexpress

Expression data from glioblastoma surgical specimens

Project description:Surgical resection is the first choice of the standardized treatment scheme for glioblastoma and is performed under general anesthesia. Previous researches have shown that propofol and sevoflurane have different effects on the biological process of glioma cells from the molecular level. Some of them, for instance, control the glioma cell proliferation, invasion and migration In vitro or In vivo. We used mRNA microarray to discuss the effects of propofol and sevoflurane on gene expression in patients with glioblastoma. The correlation between DEGs and patients’ prognosis was further analyzed.

2021-06-28 | GSE179004 | GEO

Expression data from glioblastoma surgical specimens

Project description:Expression data from glioblastoma surgical specimens

| PRJNA741898 | ENA

Surgical specimens of primary glioblastoma multiform: mRNA and miRNA profiling

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-07-13 | GSE25632 | GEO

Genome-wide analysis of primary microRNA expression using H3K36me3 ChIP-seq data.

Project description:MicroRNAs are key players in gene regulatory networks controlling cell homeostasis. Their altered expression has been previously linked to disease outcomes and microRNAs thus serve as biomarkers for disease diagnostics. However, their synthesis and its transcriptional regulation have been challenging to investigate. In this study, we validated the use of H3K36me3 histone modification for the quantification of microRNA transcription levels using data from the ENCODE Consortium and then applied this approach to provide new insight into the cell-type-specific regulation in tissues, cell line models and cardiac disease. In cardiomyocytes derived from patients suffering from septal defects, carrying a G296S mutation in the transcription factor GATA4, we show that microRNA gene transcription is altered in cardiomyocytes carrying this mutation and coincides with novel super-enhancers formed within regulatory domains defined using chromatin interaction profiles. The most prominently elevated primary transcript encodes for let-7a and miR-100 that may target genes in the Hippo signaling pathway. Collectively, our work presents a methodology to quantify microRNA gene expression using histone marker data and paves the way for functional studies of cell-type-specific transcriptional regulation occurring in disease pathology.

| S-EPMC8082160 | biostudies-literature

Genome-wide analysis of microRNA expression in Non-small Cell Lung Cancer

Project description:Analysis of NSCLC development at microRNA expression level. Results shows that has-miR-96 is significant up-regulated in the cancer tissue compared with the adjacent normal tissue. Illumina Human v2 MicroRNA expression beadchip Total microRNA obtained from 6 paired NSCLC cancer tissue and the adjacent normal tissue.

| S-ECPF-GEOD-29248 | biostudies-other

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data