Transduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation

ABSTRACT: Precise regulation of transduction signaling pathways genes is crucial for correct differentiation of kidney cells and perturbation may lead to tumor onset. Wilms tumors (WT), or nephroblastoma, originates from the metanephric blastema cells, which were unable to complete the differentiation, resulting in a triphasic tumor composed by distinct cell types, blastemal, epithelial and stromal, where the former harbor molecular characteristics similar to cells of the earliest stages of kidney development. In this study, to identify key early events involved in the disruption of correct cell signaling during kidney differentiation that can drive WT, we developed a cDNA platform containing genes from signaling transduction pathways. By using bioinformatics tools, we defined high conserved region

ORGANISM(S): Homo sapiens

SUBMITTER: Puga Renato 

PROVIDER: S-ECPF-GEOD-25965 | biostudies-other |

REPOSITORIES: biostudies-other