Expression data from melanoma subpopulations

ABSTRACT: We aimed at identifying lymphangiogenic subpopulations by comparative analysis of single cell clones derived from a melanoma of a single patient. Selected clones were grafted into SCID mice, where they induced lymphangiogenesis and metastasized into sentinel nodes, whereas non-lymphangiogenic clones from the same patient did not metastasize. RNA isolated from primary SCID mouse tumors were used for transcriptome analysis. A total of 16 Samples were analysed, 4 per group. Parental pool MCM1(C), nonlymphangiogenic MCM1G(G), lymphangiogenic MCM1D(D1), lymphangiogenic and very metastatic MCM1DLN(D2).

ORGANISM(S): Homo sapiens

SUBMITTER: Swoboda A 

PROVIDER: S-ECPF-GEOD-36035 | biostudies-other | 2012 Aug

REPOSITORIES: biostudies-other