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Effects of PD-0332991 on gene expression of human pancreatic ductal adenocarcinoma (PDAC) cell lines


ABSTRACT: PD-0332991 is a small molecule inhibitor for Cdk4 and Cdk6. It exerted growth inhibitory effects on PDAC cell lines (AsPC-1 and COLO-357). Microarray analysis was used to characterize the changes in gene expression profiles of AsPC-1 and COLO-357 upon PD-0332991 incubation AsPC-1 and COLO-357 cells were treated in the absence or presence of 5 µM PD-0332991 for 24 h and 72 h. Each expreimental condition had biological triplicates. Twenty-four samples were analyzed in total.

ORGANISM(S): Homo sapiens

SUBMITTER: Liu F 

PROVIDER: S-ECPF-GEOD-39646 | biostudies-other | 2012 Oct

REPOSITORIES: biostudies-other

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