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Pancreatic cancer and non-malignant pancreas cell lines

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE40097: DNA methylation analysis of pancreatic cancer and non-malignant pancreas cell lines GSE40098: RNA expression analysis of pancreatic cancer and non-malignant pancreas cell lines GSE41794: DNA copy number profiling of 20 pancreatic cancer cell lines Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Thu Kelsie

PROVIDER: S-ECPF-GEOD-40099 | biostudies-other |

REPOSITORIES: biostudies-other

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RNA expression analysis of pancreatic cancer and non-malignant pancreas cell lines

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| S-ECPF-GEOD-40098 | biostudies-other

Pancreatic cancer and non-malignant pancreas cell lines

Project description:This SuperSeries is composed of the following subset Series: GSE40097: DNA methylation analysis of pancreatic cancer and non-malignant pancreas cell lines GSE40098: RNA expression analysis of pancreatic cancer and non-malignant pancreas cell lines GSE41794: DNA copy number profiling of 20 pancreatic cancer cell lines Refer to individual Series

2012-11-01 | E-GEOD-40099 | biostudies-arrayexpress

Pancreatic cancer and non-malignant pancreas cell lines

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-11-01 | GSE40099 | GEO

DNA methylation analysis of pancreatic cancer and non-malignant pancreas cell lines

Project description:Genome wide DNA methylation profiling of 20 PDAC cell lines and an immortalized non-malignant pancreatic duct cell line (HPDE) to facilitate identification of novel tumor suppressor genes using an integrative genomics approach Genome wide DNA methylation profiling of 20 PDAC cell lines and an immortalized non-malignant pancreatic duct cell line (HPDE) to identify novel tumor suppressor genes Bisulphite converted DNA from the 21 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip

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RNA expression analysis of pancreatic cancer and non-malignant pancreas cell lines

2012-11-01 | E-GEOD-40098 | biostudies-arrayexpress

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2012-11-01 | GSE40098 | GEO

DNA methylation analysis of pancreatic cancer and non-malignant pancreas cell lines

2012-11-01 | GSE40097 | GEO

Different glycosylation of cadherins from human bladder non-malignant and cancer cell lines.

Project description:BackgroundThe aim of the present study was to determine whether stage of invasiveness of bladder cancer cell lines contributes to alterations in glycan pattern of their cadherins.ResultsHuman non-malignant epithelial cell of ureter HCV29, v-raf transfected HCV29 line (BC3726) and transitional cell cancers of urine bladder Hu456 and T24 were grown in cell culture. Equal amounts of protein from each cell extracts were separated by SDS-PAGE electrophoresis and were blotted on an Immobilon P membrane. Cadherins were immunodetected using anti-pan cadherin mAb and lectin blotting assays were performed, in parallel. N-oligosaccharides were analysed by specific reaction with Galanthus nivalis agglutinin (GNA), Sambucus nigra agglutinin (SNA), Maackia amurensis agglutinin (MAA), Datura stramonium agglutinin (DSA), Aleuria aurantia agglutinin (AAA), Phaseolus vulgaris agglutinin (PHA-L) and wheat germ agglutinin (WGA). The cadherin from HCV29 cell line possessed bi- and/or 2,4-branched triantennary complex type glycans, some of which were alpha2,6-sialylated. The cadherin from BC3726 cell line exhibited exclusively high mannose type glycans. Cadherins from Hu456 and T24 cell lines expressed high mannose type glycans as well as beta1,6-branched oligosaccharides with poly-N-acetyllactosamine structures and alpha2,3-linked sialic acid residues. Additionally, the presence of fucose and alpha2,6-sialic acid residues on the cadherin from T24 cell line was detected.ConclusionsThese results indicate that N-glycosylation pattern of cadherin from bladder cancer cell line undergoes modification during carcinogenesis.

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Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines.

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