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Human breast cancer SKBr-3 cells: trastuzumab-resistant vs. parental

ABSTRACT: Human breast cancer SKBr-3 cells selected with trastuzumab for 6 month compared with parental SKBr-3 cells; Goal was to screen for microRNAs involved in development of trastuzumab resistance. Human breast cancer SKBr-3 cells were continuously cultured in the presence of 5µg/ml trastuzumab for 6 months, and the resulting alive cells were regarded as trastuzumab-resistant. Total RNAs were prepared from these cells and cells cultured in parallel in control media, and were subjected to hybridization on the miRCURY LNA Array (Exiqon, version 11.0).

ORGANISM(S): Homo sapiens

SUBMITTER: Jia Lin-Tao

PROVIDER: S-ECPF-GEOD-47011 | biostudies-other |

REPOSITORIES: biostudies-other

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Human breast cancer SKBr-3 cells: trastuzumab-resistant vs. parental

2013-05-25 | GSE47011 | GEO

Human breast cancer SKBr-3 cells: trastuzumab-resistant vs. parental

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Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1.

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