Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan OSCC

ABSTRACT: Background: Oral squamous cell carcinoma (OSCC) is a major world health problem with over 400,000 new cases diagnosed annually. Despite advances in surgery and chemo-radiotherapy, the 5 year survival has remained roughly constant at approximately 50% for several decades. The disease is characterized by both clinical and genetic heterogeneity, so elucidating the molecular basis of this heterogeneity would have significant clinical implications. It is well recognized that OSCCs from Asia that are associated with betel quid chewing are phenotypically distinct from those from the West that are predominantly caused by smoking/drinking, but the genetic basis of these differences are largely unknown. The aim of this study is to examine the most related genetic factors, carcinogenic related pat

ORGANISM(S): Homo sapiens

SUBMITTER: saeed anas 

PROVIDER: S-ECPF-GEOD-51010 | biostudies-other |

REPOSITORIES: biostudies-other