14-3-3? promotes TGF-?-induced bone metastasis program in 231 cells

ABSTRACT: To explore the regulatory role of 14-3-3ζ in TGF-β induced bone metastasis program in 231 cells, we generated MDA-MB-231 human breast cancer cell sublines with 14-3-3ζ shRNA knockdown (231.ZKD-4 and 231.ZKD-5) and scrambled shRNA (231.Scr) We performed cDNA microarray analysis on these cells treated with vehicle or TGF-β (5ng/ml, 2 hours) respectively in vitro Total RNA were extracted from 231.scr, 231.ZKD-4, 231.ZKD-5 cells treated with vehicle or TGF-β, and subjected to illumina Human HT-12 v4 arrays analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Xu Jia 

PROVIDER: S-ECPF-GEOD-52066 | biostudies-other |

REPOSITORIES: biostudies-other