Characterization of Gene Expression in ASS1-Deficient Breast Cancer Cells
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ABSTRACT: Analysis of mechanism underlying the metabolic effects of ADI-PEG20 at gene expression level. The hypothesis tested in the present study was that ASS1-deficient breast cancer cells would be arginine-auxotrophs and would therefore be sensitive to arginine starvation. Results provide important information of the response of ASS1-deficient breast cancer cells to ADI-PEG20-treatment, such as the suppression of mRNAs encoding mitochondrial respiratory chain proteins. Total RNA obtained from ADI-treated, or ADI- and L-arginine-treated 231 cells compared to untreated cells.
ORGANISM(S): Homo sapiens
SUBMITTER: Qiu F
PROVIDER: S-ECPF-GEOD-53838 | biostudies-other | 2014 Apr
REPOSITORIES: biostudies-other
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