Unknown

Dataset Information

0

Characterization of Gene Expression in ASS1-Deficient Breast Cancer Cells


ABSTRACT: Analysis of mechanism underlying the metabolic effects of ADI-PEG20 at gene expression level. The hypothesis tested in the present study was that ASS1-deficient breast cancer cells would be arginine-auxotrophs and would therefore be sensitive to arginine starvation. Results provide important information of the response of ASS1-deficient breast cancer cells to ADI-PEG20-treatment, such as the suppression of mRNAs encoding mitochondrial respiratory chain proteins. Total RNA obtained from ADI-treated, or ADI- and L-arginine-treated 231 cells compared to untreated cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Qiu F 

PROVIDER: S-ECPF-GEOD-53838 | biostudies-other | 2014 Apr

REPOSITORIES: biostudies-other

Similar Datasets

2014-05-20 | GSE53838 | GEO
2014-05-20 | E-GEOD-53838 | biostudies-arrayexpress
| S-ECPF-GEOD-37139 | biostudies-other
| S-ECPF-GEOD-44836 | biostudies-other
| S-EPMC4188628 | biostudies-literature
| S-EPMC5239479 | biostudies-literature
| S-EPMC2681181 | biostudies-literature
| S-EPMC4709099 | biostudies-literature
| S-EPMC9808158 | biostudies-literature
| EGAS00001004597 | EGA