IL-17 mediates susceptibility to breast cancer growth by promoting the recruitment of tumorigenic neutrophils

ABSTRACT: The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL-17 levels. In this study, we investigated the role of IL-17 in invasive breast tumor pathogenesis. We found that metastatic tumor-infiltrating T lymphocytes produced elevated levels of IL-17, whereas IL-17 neutralization inhibited tumor growth and prevented the migration of neutrophils and tumor cells to secondary disease sites. Tumorigenic neutrophils promote disease progression, and their depletion suppressed tumor growth. Moreover, IL-17 induced IL-6 and CXCL1 production in tumor cells, and IL-6 depletion reduced metastatic tumor growth and infiltration by Th17 cells and neutrophils. In addition, inoculation of a non-metastatic mammary tumor cell line pre-incubated with IL-17 promoted tum

ORGANISM(S): Homo sapiens

SUBMITTER: De Carvalho Daniel 

PROVIDER: S-ECPF-GEOD-56822 | biostudies-other |

REPOSITORIES: biostudies-other