Pit-1 overexpression in the human breast adenocarcinoma MCF-7 cell line

ABSTRACT: The aim of the study is to evaluate Pit-1-induced genes in the MCF-7 cell line The Pit-1 transcription factor (also known as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary in mammals and is a transcriptional activator for pituitary gene transcription. Increased expression of Pit-1 has been reported in human tumorigenic breast cells. Here, we found that Pit-1 overexpression or knockdown in human breast cancer cell lines induced profound phenotypic changes in the expression of proteins involved in cell proliferation, apoptosis, and invasion. In immunodeficient mice, Pit-1 overexpression induced tumoral growth and promoted metastasis in lung. In patients with invasive ductal carcinoma of the breast and node-positive tumors elevated express

ORGANISM(S): Homo sapiens

SUBMITTER: Seoane Samuel 

PROVIDER: S-ECPF-GEOD-64101 | biostudies-other |

REPOSITORIES: biostudies-other