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MicroRNA profiling by array of bone marrow from patients with cytogenetically normal acute myeloid leukemia to study microRNA expression profiles associated with different levels of miR-3151 expression

ABSTRACT: Recently, deep sequencing of melanoma and pediatric acute lymphoblastic leukemia samples identified a new microRNA - miR-3151 - embedded in intron 1 of the BAALC gene. MiR genes are located throughout the genome, but about one-third of mammalian miRs reside within introns of host genes. Some of these intronic miRs have been found to act in functional synergism with their host genes. These findings led us to hypothesize that miR-3151 could be overexpressed in patients with elevated BAALC levels and thus might contribute to the adverse prognostic impact of its host gene, either acting in concert with BAALC or perhaps even being the element predominantly responsible for the adverse outcome observed in BAALC overexpressing AML patients.Thus, we have measured miR-151 and BAALC expression in a cohort of molecularly well characterized de novo CN-AML patients to assess the impact of miR-3151 expression alone and in combination with its host BAALC on outcome. microRNA expression profiles associated with miR-3151 expression in older patients with cytogenetically normal acute myeloid leukemia were derived using microarrays. The corresponding affymetrix data can be found under accession number E-MTAB-1075.

ORGANISM(S): Homo sapiens

SUBMITTER: Marcucci Guido

PROVIDER: S-ECPF-MTAB-1074 | biostudies-other |

REPOSITORIES: biostudies-other

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