Transcription profiling by array of human paediatric medulloblastoma samples and normal cerebellum to investigate the occurance of alternative splicing

ABSTRACT: Alternative pre-mRNA splicing critically contributes to the generation of protein variety in a tissue- and development-specific manner. Alterations in the normal pathways of alternative splicing (AS) have been associated with the growth and maintenance of several tumour types, and have been indicated as candidate bio-markers of tumour progression, metastasis and patient survival. In this study we applied genome-wide exon array technology to investigate AS events that may distinguish between human medulloblastoma and normal cerebellum. We initially investigated gene-level expression profiles to identify samples expressing gene signatures characteristic of previously described MB molecular subgroups. 3 medulloblastomas significantly over-expressed genes typically belonging to the Shh signall

ORGANISM(S): Homo sapiens

SUBMITTER: Menghi F 

PROVIDER: S-ECPF-MTAB-292 | biostudies-other | 2011 Mar

REPOSITORIES: biostudies-other