The structure of the human glutathione S-transferase pi gene.
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ABSTRACT: The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.
SUBMITTER: Cowell IG
PROVIDER: S-EPMC1135192 | biostudies-other | 1988 Oct
REPOSITORIES: biostudies-other
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