Unknown

Dataset Information

0

Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals.


ABSTRACT: It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.

SUBMITTER: Fujiwara S 

PROVIDER: S-EPMC1136261 | biostudies-other | 1995 Nov

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1220675 | biostudies-other
| S-EPMC5784979 | biostudies-literature
| S-EPMC9437251 | biostudies-literature
| S-EPMC91384 | biostudies-literature
| S-EPMC3979864 | biostudies-literature
| S-EPMC6016776 | biostudies-literature
| S-EPMC4248655 | biostudies-literature
| S-EPMC3523812 | biostudies-literature
2010-05-18 | E-GEOD-13977 | biostudies-arrayexpress
2012-04-04 | E-GEOD-36719 | biostudies-arrayexpress