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Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

ABSTRACT: Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse-transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

SUBMITTER: Karinch AM 

PROVIDER: S-EPMC1136651 | biostudies-other | 1995 Apr

REPOSITORIES: biostudies-other

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