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Inhibition of aspartic proteinases by alpha 2-macroglobulin.


ABSTRACT: The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.

SUBMITTER: Thomas DJ 

PROVIDER: S-EPMC1138603 | biostudies-other | 1989 May

REPOSITORIES: biostudies-other

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