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Glucocorticoids modulate mRNA levels for G-protein beta-subunits.


ABSTRACT: Adrenalectomy decreases, whereas glucocorticoid treatment increases, the steady-state levels of G-protein beta-subunits (G beta) in rat fat-cells. A DNA-excess solution-hybridization assay was established to define the steady-state mRNA levels for G beta [5.8 +/- 0.4 amol/micrograms of RNA (n = 5) in control fat-cells]. G beta mRNA levels decrease by 20% after adrenalectomy; dexamethasone treatment reverses the decline. Dexamethasone treatment itself increases G beta mRNA levels by 50%.

SUBMITTER: Ros M 

PROVIDER: S-EPMC1138656 | biostudies-other | 1989 May

REPOSITORIES: biostudies-other

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