Unknown

Dataset Information

0

Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.


ABSTRACT: Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

SUBMITTER: Saklatvala J 

PROVIDER: S-EPMC1144453 | biostudies-other | 1984 Dec

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1144916 | biostudies-other
| S-EPMC4710740 | biostudies-literature
| S-EPMC1158104 | biostudies-other
| S-EPMC1152527 | biostudies-other
| S-EPMC3901452 | biostudies-literature
| S-EPMC7029053 | biostudies-literature
| S-EPMC5542600 | biostudies-literature
| S-EPMC8793122 | biostudies-literature
| S-EPMC4423088 | biostudies-other
| S-EPMC1161849 | biostudies-other