Unknown

Dataset Information

0

Aboral changes in D-glucose transport by human intestinal brush-border membrane vesicles.


ABSTRACT: D-Glucose transport was investigated in isolated brush-border membrane vesicles from human small intestine. Characteristics of D-glucose transport from the jejunum were compared with that in the mid and terminal ileum. Jejunal and mid-ileal D-glucose transport was Na+-dependent and electrogenic. The transient overshoot of jejunal D-glucose transport was significantly greater than corresponding values in mid-ileum. The terminal ileum did not exhibit Na+-dependent D-glucose transport, but did exhibit Na+-dependent taurocholate transport. Na+-glucose co-transport activity as measured by tracer-exchange experiments was greatest in the jejunum, and diminished aborally. We conclude that D-glucose transport in man is Na+-dependent and electrogenic in the proximal intestine and directly related to the activity of D-glucose-Na+ transporters present in the brush-border membranes. D-Glucose transport in the terminal ileum resembles colonic transport of D-glucose.

SUBMITTER: Bluett MK 

PROVIDER: S-EPMC1146969 | biostudies-other | 1986 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1161041 | biostudies-other
| S-EPMC1147116 | biostudies-other
| S-EPMC1161516 | biostudies-other
| S-EPMC1727494 | biostudies-other
| S-EPMC1161307 | biostudies-other
| S-EPMC1183801 | biostudies-other
| S-EPMC1186506 | biostudies-other
| S-EPMC6353940 | biostudies-literature
| S-EPMC1186515 | biostudies-other
| S-EPMC1164262 | biostudies-other