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Sex- and phenotype-dependent metabolism of N tau-methylhistidine by mice.


ABSTRACT: The metabolism of N tau-[Me-14C]methylhistidine by mice was influenced by both the sex and the phenotype of the animal. After subcutaneous injection of labelled N tau-methylhistidine, recoveries of radioactivity in excreta were incomplete, and the distributions of radioactivity showed that different mouse phenotypes degraded N tau-methylhistidine in vivo to different extents. Hence the excretion of N tau-methylhistidine by mice cannot be used as an index of protein breakdown in vivo.

SUBMITTER: Harris CI 

PROVIDER: S-EPMC1147265 | biostudies-other | 1986 Oct

REPOSITORIES: biostudies-other

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