Unknown

Dataset Information

0

Acute-phase high-density lipoprotein in the rat does not contain serum amyloid A protein.


ABSTRACT: Serum amyloid A protein (SAA) is an acute-phase apolipoprotein of high-density lipoprotein (HDL). Its N-terminal sequence is identical with that of amyloid A protein (AA), the subunit of AA amyloid fibrils. However, rats do not develop AA amyloidosis, and we report here that neither normal nor acute-phase rat HDL contains a protein corresponding to SAA of other species. mRNA coding for a sequence homologous with the C-terminal but not with the N-terminal part of human SAA is synthesized in greatly increased amounts in acute-phase rat liver. These observations indicate that the failure of rats to develop AA amyloid results from the absence of most of the AA-like part of their SAA-like protein, and that the N-terminal portion of SAA probably contains the lipid-binding sequences.

SUBMITTER: Baltz ML 

PROVIDER: S-EPMC1147699 | biostudies-other | 1987 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC5794427 | biostudies-literature
| S-EPMC3408152 | biostudies-literature
| S-EPMC6109913 | biostudies-literature
| S-EPMC3330163 | biostudies-literature
| S-EPMC1148637 | biostudies-other
| S-EPMC1219714 | biostudies-other
| S-EPMC4349446 | biostudies-literature
| S-EPMC11330610 | biostudies-literature
| S-EPMC7072968 | biostudies-literature
| S-EPMC3380531 | biostudies-literature