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Development of multiple activities of UDP-glucuronyltransferase in human liver.

ABSTRACT: UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a 'foetal' form of UDP-glucuronyltransferase may exist in human liver that is more restricted in substrate specificity than are those of the rat or rhesus monkey.

SUBMITTER: Leakey JE

PROVIDER: S-EPMC1147936 | biostudies-other | 1987 May

REPOSITORIES: biostudies-other

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