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Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans.


ABSTRACT: The nematode worm Caenorhabditis elegans is known to undergo characteristic morphological as well as physiological signs of senescence. Two-dimensional gel electrophoresis shows that alterations also occur in the pattern of the nuclear proteins as a function of age. Non-histone proteins whose level exhibits a steep fall with age are egg-specific and not involved in senescence. However, a distinct set of non-histones accumulates with age and can be considered as senescence markers. Some of these are glycoproteins, as shown by their concanavalin A-binding properties. One age-specific polypeptide, called 'protein S-28', was further characterized by peptide mapping and determination of its N-terminal amino acid sequence.

SUBMITTER: Meheus LA 

PROVIDER: S-EPMC1148108 | biostudies-other | 1987 Jul

REPOSITORIES: biostudies-other

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