Unknown

Dataset Information

0

Arrangement of the disulphide bridges in human low-Mr kininogen.


ABSTRACT: The arrangement of the disulphide bridges in human low-Mr kininogen has been elucidated. Low-Mr kininogen contains 18 half-cystine residues forming nine disulphide bridges. The first and the last half-cystine residues of the amino acid sequence form a disulphide loop which spans the heavy- and the light-chain portion of the kininogen molecule. The other 16 half-cystine residues are linked consecutively to form eight loops of 4-20 amino acids; these loops are lined up in the heavy-chain portion of the kininogen molecule. In this way, a particular pattern of disulphide loops is formed which seems to be of critical importance for the inhibitor function of human kininogen.

SUBMITTER: Kellermann J 

PROVIDER: S-EPMC1148362 | biostudies-other | 1987 Oct

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2756234 | biostudies-literature
| S-EPMC1270086 | biostudies-other
| S-EPMC1176558 | biostudies-other
| S-EPMC1148212 | biostudies-other
| S-EPMC3380823 | biostudies-literature
| S-EPMC1198434 | biostudies-other
| S-EPMC1270114 | biostudies-other
| S-EPMC1172409 | biostudies-other
| S-EPMC1146582 | biostudies-other
| S-EPMC1178493 | biostudies-other