Unknown

Dataset Information

0

Lithium inhibits muscarinic-receptor-stimulated inositol tetrakisphosphate accumulation in rat cerebral cortex.


ABSTRACT: The effects of Li+ on carbachol-stimulated phosphoinositide metabolism were examined in rat cerebral-cortex slices labelled with myo-[2-3H]inositol. The muscarinic agonist carbachol evoked an enhanced steady-state accumulation of [3H]inositol monophosphate ([3H]InsP1), [3H]inositol bisphosphate ([3H]InsP2), [3H]inositol 1,3,4-trisphosphate ([3H]Ins(1,3,4)P3), [3H]inositol 1,4,5-trisphosphate ([3H]Ins(1,4,5)P3) and [3H]inositol tetrakisphosphate ([3H]InsP4). Li+ (5 mM), after a 10 min lag, severely attenuated carbachol-stimulated [3H]InsP4 accumulation while simultaneously potentiating accumulation of both [3H]InsP1 and [3H]InsP2 and, at least initially, of [3H]Ins(1,3,4)P3. These data are consistent with inhibition of inositol mono-, bis- and 1,3,4-tris-phosphate phosphatases to different degrees by Li+ in brain, but are not considered to be completely accounted for in this way. Potential direct and indirect mechanisms of the inhibitory action of Li+ on [3H]InsP4 accumulation are considered. The present results stress the complex action of Li+ on cerebral inositol metabolism and indicate that more complex mechanisms than are yet evident may regulate this process.

SUBMITTER: Batty I 

PROVIDER: S-EPMC1148483 | biostudies-other | 1987 Nov

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1133184 | biostudies-other
| S-EPMC1131366 | biostudies-other
| S-EPMC1138651 | biostudies-other
| S-EPMC1131374 | biostudies-other
| S-EPMC1152860 | biostudies-other
| S-EPMC2747319 | biostudies-literature
| S-EPMC1138319 | biostudies-other
| S-EPMC5799274 | biostudies-literature
| S-EPMC1132534 | biostudies-other
| S-EPMC2084373 | biostudies-literature