Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles.
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ABSTRACT: The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.
SUBMITTER: Takao F
PROVIDER: S-EPMC1149686 | biostudies-other | 1990 Nov
REPOSITORIES: biostudies-other
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