Ontology highlight
ABSTRACT:
SUBMITTER: Asano S
PROVIDER: S-EPMC1150880 | biostudies-other | 2005 Jun
REPOSITORIES: biostudies-other
Asano Satoshi S Park Jung-Eun JE Sakchaisri Krisada K Yu Li-Rong LR Song Sukgil S Supavilai Porntip P Veenstra Timothy D TD Lee Kyung S KS
The EMBO journal 20050526 12
In eukaryotes, entry into mitosis is induced by cyclin B-bound Cdk1, which is held in check by the protein kinase, Wee1. In budding yeast, Swe1 (Wee1 ortholog) is targeted to the bud neck through Hsl1 (Nim1-related kinase) and its adaptor Hsl7, and is hyperphosphorylated prior to ubiquitin-mediated degradation. Here, we show that Hsl1 and Hsl7 are required for proper localization of Cdc5 (Polo-like kinase homolog) to the bud neck and Cdc5-dependent Swe1 phosphorylation. Mitotic cyclin (Clb2)-bou ...[more]