Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.
Ontology highlight
ABSTRACT: Stoicheiometric amounts of [14C]disulfiram react rapidly with sheep liver cytoplasmic aldehyde dehydrogenase to give loss of catalytic activity and incorporation of the expected amount of radioactivity. In a subsequent slower reaction the label is lost from the enzyme without re-emergence of enzymic activity. The results imply that in vivo disulfiram may act as an oxidation-reduction catalyst for the inactivation of aldehyde dehydrogenase.
SUBMITTER: Kitson TM
PROVIDER: S-EPMC1152162 | biostudies-other | 1983 Aug
REPOSITORIES: biostudies-other
ACCESS DATA