The role of GTP in prostaglandin E1 stimulation of adenylate cyclase in platelet membranes.

ABSTRACT: Adenylate cyclase activity in platelet membrane preparations was measured in the presence of prostaglandin E1 (PGE1), GTP and a non-hydrolysable analogue of GDP, guanosine 5'-[beta-thio]diphosphate (GDP[beta S]). A dose-dependent inhibition of adenylate cyclase by GDP[beta S] was observed that could be reversed either by adding increased amounts of GTP or of PGE1.

SUBMITTER: Stein JM 

PROVIDER: S-EPMC1152231 | biostudies-other | 1983 Jul

REPOSITORIES: biostudies-other