Unknown

Dataset Information

0

Two individuals with elliptocytic red cells apparently lack three minor erythrocyte membrane sialoglycoproteins.


ABSTRACT: We have studied the erythrocytes of two individuals (P. L. and K. W.) who lack the Gerbich (Ge) blood-group antigen. The erythrocytes of P. L. and K. W. were not reactive with two monoclonal antibodies (NBTS/BRIC 4 and NBTS/BRIC 10) which reacted with normal erythrocytes. The membranes of P. L. and K. W. erythrocytes appeared to lack three minor sialoglycoproteins (beta, beta 1 and gamma). These three minor sialoglycoproteins were found to be associated with the cytoskeletons of normal erythrocytes. Approx. 10% of the erythrocytes of P. L. and K. W. were frankly elliptocytic. We suggest that one or more of the minor sialoglycoproteins may play a part in maintaining the discoid shape of the human erythrocyte.

SUBMITTER: Anstee DJ 

PROVIDER: S-EPMC1153379 | biostudies-other | 1984 Mar

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1144007 | biostudies-other
| S-EPMC5465837 | biostudies-literature
| S-EPMC1135146 | biostudies-other
| S-EPMC5530273 | biostudies-other
| S-EPMC10529852 | biostudies-literature
| S-EPMC6117401 | biostudies-literature
| S-EPMC1147962 | biostudies-other
| S-EPMC3029348 | biostudies-literature
| S-EPMC3277354 | biostudies-literature
2019-08-22 | PXD013852 | Pride