Unknown

Dataset Information

0

Characteristics of the desensitization and resensitization of the cyclic AMP-independent glycogenolytic response in rat liver cells.


ABSTRACT: Vasopressin and alpha-adrenergic agonists were shown previously [Bréant, Keppens & De Wulf (1981) Biochem. J. 200, 509-514] to induce a heterologous, dose-dependent and receptor-mediated desensitization of the cyclic AMP-independent glycogenolytic response in isolated hepatocytes. The desensitized state of the hepatocytes can be preserved as long as the agonist is bound to its receptor. Conversely, washing the cells with a hormone-free buffer or displacement of the agonist from its receptor by a specific antagonist restores the responsiveness. The desensitization and its reversibility (i.e. resensitization) are obtained within minutes. The desensitization can be clearly elicited at temperatures as low as 5 degrees C, whereas the glycogenolytic response and the enhancement of the 45Ca flux are only obtained above 15 degrees C; the resensitization requires even higher temperatures. A tentative model is proposed to account for the observed effects.

SUBMITTER: Keppens S 

PROVIDER: S-EPMC1153966 | biostudies-other | 1982 Nov

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1163571 | biostudies-other
| S-EPMC1132588 | biostudies-other
| S-EPMC5527385 | biostudies-literature
| S-EPMC1565491 | biostudies-literature
| S-EPMC6440977 | biostudies-literature
| S-EPMC4556939 | biostudies-literature
| S-EPMC1184141 | biostudies-other
| S-EPMC1148992 | biostudies-other
2015-07-01 | GSE67968 | GEO
| S-EPMC1162860 | biostudies-other