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Affinity change of the adipocyte receptor fails to alter insulin-stimulated glucose transport.


ABSTRACT: Occupancy increased the affinity of the insulin receptor of the adipocyte. During the affinity change the half-maximal sensitivity of glucose transport to insulin stimulation was unaltered. Decreased maximum response of transport only occurred after the affinity change. There was not a simple relationship between receptor affinity and insulin stimulation of glucose transport in the adipocyte.

SUBMITTER: McCaleb ML 

PROVIDER: S-EPMC1158101 | biostudies-other | 1982 Jan

REPOSITORIES: biostudies-other

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