The effects of orthovanadate on fatty acid synthesis in isolated rat hepatocytes.

ABSTRACT: Extracellular Ca2+ stimulated fatty acid synthesis in isolated rat hepatocytes. Orthovanadate (0.2--2.0 mM), an inhibitor of Ca2+-dependent ATPases, stimulated fatty acid synthesis in both the presence and the absence of extracellular Ca2+. Insulin stimulated fatty acid synthesis only in the presence of extracellular Ca2+. The contribution of extracellular Ca2+ to insulin stimulation of fatty acid synthesis is discussed.

SUBMITTER: Agius L 

PROVIDER: S-EPMC1158177 | biostudies-other | 1982 Mar

REPOSITORIES: biostudies-other