Unknown

Dataset Information

0

Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands.


ABSTRACT: Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.

SUBMITTER: Litosch I 

PROVIDER: S-EPMC1158326 | biostudies-other | 1982 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1158354 | biostudies-other
| S-EPMC1133713 | biostudies-other
| S-EPMC5388535 | biostudies-literature
| S-EPMC4175343 | biostudies-literature
| S-EPMC6617833 | biostudies-literature
| S-EPMC1158327 | biostudies-other
| S-EPMC1144183 | biostudies-other
| S-EPMC10196562 | biostudies-literature
| S-EPMC3493529 | biostudies-literature
2016-05-25 | GSE79716 | GEO