Unknown

Dataset Information

0

Inhibition of renin by conformationally restricted analogues of angiotensinogen.


ABSTRACT: [Cys(5),Cys(10)]Angiotensinogen-(5-14)-peptide analogues and homologues were synthesized, in which a disulphide bond between residues 5 and 10 stabilized a 9-->6 beta-turn proposed for the substrate. These compounds were competitive inhibitors of human and pig renins with K(i) values of the order of 10(-6)-10(-5)m, indicating that the conformation proposed for the substrate is important for the interaction with the enzyme.

SUBMITTER: Nakaie CR 

PROVIDER: S-EPMC1158444 | biostudies-other | 1982 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6734540 | biostudies-literature
| S-EPMC5508670 | biostudies-literature
| S-EPMC10730775 | biostudies-literature
| S-EPMC5423080 | biostudies-literature
| S-EPMC6378967 | biostudies-literature
| S-EPMC2577068 | biostudies-literature
| S-EPMC9861757 | biostudies-literature
| S-EPMC2765511 | biostudies-literature
| S-EPMC8001838 | biostudies-literature
| S-EPMC8649030 | biostudies-literature