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A simple test for macromolecular heterogeneity in the analytical ultracentrifuge.


ABSTRACT: A simple check for the presence of heterogeneity in a macromolecular system is proposed, employing comparison of Rayleigh sedimentation-equilibrium patterns for two solutions of the same fringe concentration but differing absolute concentrations. The method is illustrated by application to a bronchial glycoprotein from a cystic-fibrosis patient.

SUBMITTER: Creeth JM 

PROVIDER: S-EPMC1158533 | biostudies-other | 1982 Sep

REPOSITORIES: biostudies-other

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