Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid.
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ABSTRACT: Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.
SUBMITTER: Badawy AA
PROVIDER: S-EPMC1158564 | biostudies-other | 1982 Jul
REPOSITORIES: biostudies-other
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