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Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid.


ABSTRACT: Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.

SUBMITTER: Badawy AA 

PROVIDER: S-EPMC1158564 | biostudies-other | 1982 Jul

REPOSITORIES: biostudies-other

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