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KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites.


ABSTRACT: KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-based prediction tool for identifying protein phosphorylation sites. Therefore, this work developed a kinase-specific phosphorylation site prediction tool with both high sensitivity and specificity. The prediction tool is freely available at http://KinasePhos.mbc.nctu.edu.tw/.

SUBMITTER: Huang HD 

PROVIDER: S-EPMC1160232 | biostudies-other | 2005 Jul

REPOSITORIES: biostudies-other

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KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites.

Huang Hsien-Da HD   Lee Tzong-Yi TY   Tzeng Shih-Wei SW   Horng Jorng-Tzong JT  

Nucleic acids research 20050701 Web Server issue


KinasePhos is a novel web server for computationally identifying catalytic kinase-specific phosphorylation sites. The known phosphorylation sites from public domain data sources are categorized by their annotated protein kinases. Based on the profile hidden Markov model, computational models are learned from the kinase-specific groups of the phosphorylation sites. After evaluating the learned models, the model with highest accuracy was selected from each kinase-specific group, for use in a web-b  ...[more]

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