Unknown

Dataset Information

0

Precocious development of cytochrome P-450 in neonatal rat liver after glucocorticoid treatment.


ABSTRACT: Intraperitoneal injection of neonatal rats with glucocorticoid hormones causes precocious development of hepatic cytochrome P-450. Glucagon injection fails to stimulate this cytochrome P-450 development. Adult liver cytochrome P-450 is less responsive to glucocorticoid stimulation than is that of neonatal rat liver. Adrenalectomy of prematurely delivered neonatal animals prevents the early postnatal development of cytochrome P-450. Glucocorticoids failed to increase cytochrome P-450 concentrations in foetal rat liver. These findings imply that, although glucocorticoids are mandatory regulatory factors controlling cytochrome P-450 development, they are not themselves the 'trigger' initiating onset of that development.

SUBMITTER: Leakey JE 

PROVIDER: S-EPMC1161253 | biostudies-other | 1979 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1153350 | biostudies-other
| S-EPMC1162154 | biostudies-other
| S-EPMC5321625 | biostudies-other
| S-EPMC4658375 | biostudies-literature
| S-EPMC7689907 | biostudies-literature
| S-EPMC1198444 | biostudies-other
| S-EPMC1135799 | biostudies-other
| S-EPMC1164298 | biostudies-other
| S-EPMC1165772 | biostudies-other
| S-EPMC1132093 | biostudies-other