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5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat.

ABSTRACT: 5,6-Epoxyretinoic acid was detected in small intestine, kidney, liver, testes and serum of vitamin A-deficient rats 3 h after a single physiological dose of [3H]retinoic acid. The maximum concentration of 5,6-epoxide in intestinal mucosa was observed 3 h after intrajugular administration of retinoic acid. However, at 7 h post administration, no 5,6-epoxyretinoic acid was detected in mucosa, demonstrating the rapid intestinal metabolism or excretion of this metabolite. No 5,6-epoxy[3H]retinoic acid was detected in mucosa, liver or serum of retinoic acid-repleted rats 3 h after administration of 2 micrograms of [3H]retinoic acid.

SUBMITTER: McCormick AM

PROVIDER: S-EPMC1161599 | biostudies-other | 1980 Feb

REPOSITORIES: biostudies-other

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