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Quantitative importance of non-skeletal-muscle sources of N tau-methylhistidine in urine.


ABSTRACT: Direct measurement of N tau-methylhistidine turnover in skeletal muscle, skin and gastrointestinal muscle indicates that these three tissues contribute only 24.9, 6.8 and 9.8% of the total urinary excretion. Measurement of the decay rate of radioactively labelled N tau-methylhistidine in urine indicates that skeletal muscle accounts for 74.5% of the urinary excretion and this is probably an overestimate. These results suggest that the common assumption, that N tau-methylhistidine in urine originates almost entirely from skeletal muscle, may be wrong.

SUBMITTER: Millward DJ 

PROVIDER: S-EPMC1162081 | biostudies-other | 1980 Jul

REPOSITORIES: biostudies-other

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