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Evolutionary significance of the renal excretion of transferrin half-molecule fragments.


ABSTRACT: It is generally thought that the duplicated structure of serum transferrin in vertebrates arose by gene duplication and fusion from a small ancestral protein. We have found that the isolated domains of transferrin are rapidly lost from the bloodstream via the kidneys. Therefore we suggest that the ancestral transferrin was not a serum protein or, alternatively, that it was not as small as the half-molecule.

SUBMITTER: Williams J 

PROVIDER: S-EPMC1163659 | biostudies-other | 1982 Feb

REPOSITORIES: biostudies-other

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