Unknown

Dataset Information

0

Biologically active macromolecular forms of oxytocin. [8-Lysine]oxytocin as a suitable ligand.


ABSTRACT: [8-Lysine]oxytocin was synthesized on a solid support and possessed an oxytocic activity of 100 +/- 6 units mumol on the isolated rat uterus. The epsilon-carbamoyl, epsilon-3-carboxypropionyl and epsilon-3-carboxybutryl derivatives were prepared and had uterotonic activities of 400, 55 and 50 units/mumol respectively. [8-Lysine]oxytocin was coupled unambiguously through the epsilon-amino group to the carboxyl groups of carboxymethylated dextrans or epsilon-3-carboxypropionly-gelatin. The macromolecular oxytocins were water-soluble and retained signigicant oxytocic activity. [8-Lysine]oxytocin should prove a useful ligand for affinity chromatography of oxytocin-binding proteins.

SUBMITTER: Snell CR 

PROVIDER: S-EPMC1164866 | biostudies-other | 1977 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6769701 | biostudies-literature
| S-EPMC6090651 | biostudies-literature
| S-EPMC6099872 | biostudies-other
| S-EPMC7504936 | biostudies-literature
| S-EPMC6253249 | biostudies-literature
| S-EPMC7842209 | biostudies-literature
| S-EPMC7821050 | biostudies-literature
| S-EPMC8198555 | biostudies-literature
| S-EPMC8211860 | biostudies-literature
| S-EPMC2957841 | biostudies-literature