Unknown

Dataset Information

0

Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II).


ABSTRACT: Goat antibodies to pig lung angiotensin-converting enzyme (kininase II) were conjugated to microperoxidase. Rat lung tissue, previously incubated with non-immune goat serum, was incubated with the antibody-microperoxidase conjugate and then with H2O2 and 3,3-diaminobenzidine. Electron microscopy revealed reaction product on the plasma membrane and caveolae of endothelial cells, especially those of capillaries and venules. These results support the hypothesis that angiotensin I and bradykinin are metabolized by enzymes on the luminal surface of pulmonary endothelial cells.

SUBMITTER: Ryan JW 

PROVIDER: S-EPMC1165329 | biostudies-other | 1975 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC7532484 | biostudies-literature
| S-EPMC6483501 | biostudies-literature
| S-EPMC1163875 | biostudies-other
| S-EPMC2732127 | biostudies-literature
| S-EPMC3072070 | biostudies-literature
| S-EPMC2657551 | biostudies-literature
| S-EPMC5493495 | biostudies-literature
| S-EPMC10864204 | biostudies-literature
| S-EPMC1218999 | biostudies-other
| S-EPMC8361046 | biostudies-literature