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A sensitive radiochemical assay for angiotensin-converting enzyme (kinase II).


ABSTRACT: [[125I]Tyr8]Bradykinin is degraded by angiotensin-converting enzyme to [125I]Tyr-Arg. The reaction product can be separated completely and recovered nearly quantitatively from unchanged substrate by cation-exchange chromatography. Thus it is possible to use [[125I]Tyr8]bradykinin at high specific radioactivity (about 400Ci/mmol) to measure the small quantities of angiotensin-converting enzyme encountered in small-scale cultures of pulmonary endothelial cells.

SUBMITTER: Chiu AT 

PROVIDER: S-EPMC1165618 | biostudies-other | 1975 Jul

REPOSITORIES: biostudies-other

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